国家自然科学奖二等奖
项目名称：双面对称核苷的设计合成与抗口腔黏膜病相关病毒作用机制研究
提名者：中华口腔医学会
代表性论文（专著）目录：
- haozhe yang, meiying pan, dawei jiang, yang he*. synthesis of janus type nucleoside analogues and their preliminary bioactivity. organic & biomolecular chemistry 2011, 9(5): 1516-1522.
- hang zhao#, xiurong guo#, shiling he#, xin zeng, xinglong zhou, chaoliang zhang, jing hu, xiaohua wu, zhihua xing, liangyin chu, yang he*, qianming chen*. complex self-assembly of pyrimido [4, 5-d] pyrimidine nucleoside supramolecular structures. nature communications 2014, 5(1): 3108.
- hang zhao#, hui feng#, dongjuan liu#, jiang liu, ning ji, fangman chen, xiaobo luo, yu zhou, hongxia dan, jing li, congkui sun, xiaojie meng, ming zhou, hansuo yang, liangyin chu, lu jiang*, yang he*, qianming chen*. self-assembling monomeric nucleoside molecular nanoparticles loaded with 5-fu enhancing therapeutic efficacy against oral cancer. acs nano 2015, 9(10): 9638-9651.
- hang zhao, wen huang, xiaohua wu, zhihua xing, yang he*, qianming chen*. different superstructures formed by janus-type nucleosides. chemical communications 2012, 48(49): 6097-6099.
- jiang liu#, hang zhao#, xinglong zhou, yang he*, qianming chen*. antiviral activities of janus-type nucleosides and their related oxime-intermediates. bioorganic & medicinal chemistry 2019, 27(12): 2332-2339.
主要完成人（完成单位）：陈谦明（四川大学）、何杨（四川大学）、赵行（四川大学）、曾昕（四川大学）、刘江（四川大学）